Primary concern of GRDDS is the programmability. They programmed/designed to retain the drug in stomach for a prolonged period time and release the drug in a controlled manner, so that the drug could be supplied continuously to its absorption sites in the GIT (on-site drug release). The major advantages with this novel approach includes- enhanced bioavailability, reduced frequency of dosing, targeted therapy, reduced counter-activity of the body, minimized adverse activity at the colon, and reduced fluctuations of plasma drug concentration. Number of techniques has been used to increase the gastric retention time (GRT) of dosage forms by employing a variety of concepts like floating, swelling, inflation, adhesion, high density, and magnetic systems. All these technical approaches and the drug selection criteria were discussed briefly in this review along with various formulation considerations, requirements, methods to asses gastroretentivity of gatroretentive dosage forms (GRDFs), and the factors controlling gastric retention of dosage forms.
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